Medicine

Niacin, meals intake and heart effects

.Nature Medicine, Released online: 05 September 2024 doi:10.1038/ s41591-024-03220-2Niacin, food int...

Opportunities and obstacles for patient-reported outcome examination in multimorbidity study as well as technique

.Contending rate of interests.S.E.H. acquires backing coming from the National Principle of Health A...

Hibernation science harnessed to alleviate being overweight and also modify metabolism

.Attributes Medication, Released online: 04 September 2024 doi:10.1038/ s41591-024-03226-wBy recogni...

CAR- T as well as cell genetics treatments are actually too expensive

.Nature Medication, Posted online: 04 September 2024 doi:10.1038/ s41591-024-03231-zPoint-of-care ma...

The WHO genomics system of work for nondiscriminatory application of human genomics for worldwide health and wellness

.The publication of the initial draft of the human genome pattern in 20011 was actually adhered to b...

A time-stratified, case\u00e2 $ \"crossover research study of heat visibility and perinatal mortality coming from 16 health centers in sub-Saharan Africa

.Among 138,015 hospital-based singleton births in 4 sub-Saharan African nations, our team noted proo...

Advancing global antibiotic investigation, development as well as access #.\n\nMurray, C. J. L. et al. Global worry of bacterial antimicrobial resistance in 2019: an organized review. Lancet 399, 629\u00e2 $ \"655 (2022 ). AMR Leaders. Towards specific dedications and activity in the response to antimicrobial protection. Global Leaders Group on Antimicrobial Resistance https:\/\/www.amrleaders.org\/resources\/m\/item\/glg-report (4 April 2024). Planet Health And Wellness Company. WHO posts list of microorganisms for which new anti-biotics are quickly needed. Globe Health and wellness Association https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed (27 February 2017). World Wellness Company. WHO microbial top priority virus list, 2024: bacterial pathogens of public health usefulness to lead study, progression as well as tactics to avoid as well as regulate antimicrobial protection. Globe Wellness Association https:\/\/www.who.int\/publications\/i\/item\/9789240093461 (17 May 2024). Silver, L. L. A Gestalt way to Gram-negative entrance. Bioorg. Med. Chem. 24, 6379\u00e2 $ \"6389 (2016 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nSundqvist, M. Reversibility of antibiotic protection. Ups. J. Med. Sci. 119, 142\u00e2 $ \"148 (2014 ).\nGoogle.com Scholar\u00c2.\nPlanet Health And Wellness Institution. 2023 antibacterial brokers in medical as well as preclinical advancement: an overview and also analysis. Planet Health and wellness Organization https:\/\/www.who.int\/publications\/i\/item\/9789240094000 (14 June 2024). O' Neill, J. et al. AMR Assessment. May 19, 2016 \u00e2 $\" Tackling drug-resistant diseases worldwide: last record and also suggestions. Assessment on Antimicrobial Resistance https:\/\/amr-review.org\/Publications.html (19 May 2016). Drive-AB Consortium. DRIVE-AB outcomes: records and also rundown. Drive AB https:\/\/drive-ab.eu\/drive-ab-outputs\/drive-ab-reports\/ (2016 ). Stern, S. et cetera. Breaking through the wall: a call for collective activity on anti-biotics research and development. Boston Consulting Team https:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/Dateien\/5_Publikationen\/Gesundheit\/Berichte\/GUARD_Follow_Up_Report_Full_Report_final.pdf (February, 2017). Anderson, M., Panteli, D. &amp Mossialos, E. Policy Quick 51: How can the EU assistance sustainable innovation and accessibility to successful prescription antibiotics? policy choices for existing and also brand new medications. European Observatory on Wellness Systems as well as Policies https:\/\/eurohealthobservatory.who.int\/publications\/i\/how-can-the-eu-support-sustainable-innovation-and-access-to-effective-antibiotics-policy-options-for-existing-and-new-medicines (21 June 2023). Turnidge, J. &amp Christiansen, K. Prescription antibiotic usage as well as resistance\u00e2 $\" verifying the apparent. Lancet 365, 548\u00e2 $ \"549 (2005 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nGlobe Wellness Institution. 2021 AWaRe distinction. WHO access, check out, book, distinction of antibiotics for examination and monitoring of making use of. Planet Health Company https:\/\/www.who.int\/publications\/i\/item\/2021-aware-classification (30 September 2021). International Center for Disease Prevention and Control. Antimicrobial protection targets: how can our company reach all of them by 2030? ECDC https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/amr-brief-eaad-2023-update.pdf (2023 ). Planet Health Institution. Shortage of innovation readied to weaken antibiotic efficiency and wellness increases. World Health Association https:\/\/www.who.int\/news\/item\/22-06-2022-22-06-2022-lack-of-innovation-set-to-undermine-antibiotic-performance-and-health-gains (22 June 2022). Magnano San, L. R. et cetera. Just how antimicrobial protection is actually connected to environment improvement: an outline of 2 entwined international difficulties. Int. J. Environ. Res. Hygienics twenty, 1681 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nDolecek, C., Shakoor, S., Basnyat, B., Okwor, T. &amp Sartorius, B. Drug-resistant bacterial contaminations: we require emergency activity as well as assets that pay attention to the weakest hyperlink. PLoS Biol. Twenty, e3001903 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nGlobe Wellness Institution. Immunization insurance coverage. Globe Health Company https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/immunization-coverage (15 July 2024). Chimhini, G., Magwenzi, M. &amp Fitzgerald, F. C. Contamination prevention and management in low-resource settings: the need for the nearby, the contextual as well as the practical. Corrupt. Prev. Pract. 4, 100135 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNour, S., Stokle, E., Ashiru-Oredope, D. &amp Wesangulae, E. Challenges of carrying out antimicrobial stewardship resources in reduced to center earnings countries (LMICs). Affect. Prev. Pract. 5, 100315 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nAminov, R. A brief record of the antibiotic time: trainings learned and problems for the future. Face. Microbiol. 1, 134 (2010 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nOutterson, K. et cetera. Individual access in 14 high-income nations to new antibacterials accepted by the US Food and Drug Administration, European Medicines Company, Japanese Pharmaceuticals and also Medical Devices Firm, or even Wellness Canada, 2010\u00e2 $ \"2020. Clin. Contaminate. Dis. 74, 1183\u00e2 $ \"1190 (2022 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nWorld Wellness Association. 2021 anti-bacterial agents in clinical and preclinical advancement: an introduction as well as study. Planet Health and wellness Institution https:\/\/www.who.int\/publications\/i\/item\/9789240047655 (27 May 2022). Anti-biotics: the business economics should assist the scientific research. Attributes 625, 7 (2024 ). Thomas, D. &amp Wessel, C. The state of technology in anti-bacterial rehabs. Medical Technology Company https:\/\/www.bio.org\/sites\/default\/files\/2022-02\/The-State-of-Innovation-in-Antibacterial-Therapeutics.pdf (February, 2022). Strich, J. et cetera. Evaluating clinician usage of next-generation prescription antibiotics versus resisting Gram-negative diseases in USA health centers: a retrospective accomplice study. Ann. Intern. Medication. 177, 559\u00e2 $ \"572 (2024 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nThomas, D. &amp Wessel, C. The state of innovation in anti-bacterial therapeutics. Biotechnology Innovation Institution https:\/\/www.bio.org\/sites\/default\/files\/2022-04\/BIO-Antibacterial-Report-2022.pdf (February 2022). Renwick, M. J., Brogan, D. M. &amp Mossialos, E. A systematic review and also critical analysis of reward tactics for exploration as well as advancement of novel antibiotics. J. Antibiot. 69, 73\u00e2 $ \"88 (2016 ). Article\u00c2.\nCAS\u00c2.\n\nGoogle Scholar\u00c2.\nWellness Urgent Readiness and Action Authorization. Trial and error of clinical countermeasures. International Percentage https:\/\/health.ec.europa.eu\/health-emergency-preparedness-and-response-hera\/preparedness\/research-and-development-medical-countermeasures_en (2024 ). European Commission. Pre-draft plan for an International partnership under Horizon Europe One Health And Wellness Antimicrobial Protection. European Percentage https:\/\/research-and-innovation.ec.europa.eu\/system\/files\/2022-02\/ec_rtd_he-partnerships-onehealth-amr.pdf (9 February 2022). Worldwide Anti-biotic Trial And Error Collaboration. Entasis Therapeutics and the Global Prescription Antibiotic Investigation &amp Progression Relationship to build a brand new procedure for gonorrhea. GARDP https:\/\/gardp.org\/entasis-therapeutics-and-the-global-antibiotic-research-development-partnership-to-develop-a-new-treatment-for-gonorrhea\/ (6 July 2017). Atal, I., Trinquart, L., Porcher, R. &amp Ravaud, P. Differential globalization of industry- and non-industry-sponsored clinical trials. PLoS ONE 10, e0145122 (2015 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nGlobe Health Institution. Variety of professional trial signs up through location, condition, period of progression, grow older as well as sex of test attendees (1999\u00e2 $ \"2022). Planet Wellness Association https:\/\/www.who.int\/observatories\/global-observatory-on-health-research-and-development\/monitoring\/number-of-trial-registrations-by-year-location-disease-and-phase-of-development (February 2023). Global Antibiotic Research and Development Collaboration. NeoSept1: a research study to find out the ranking of existing and brand-new prescription antibiotics blends to treat newborns who remain in health center with severe blood poisoning. ISRCTN registry https:\/\/www.isrctn.com\/ISRCTN48721236 (17 January 2022). Public Health Agency of Canada. Authorities of Canada brings in significant assets to overcome antimicrobial protection (AMR), Federal government of Canada https:\/\/www.canada.ca\/en\/public-health\/news\/2023\/05\/government-of-canada-makes-important-investment-to-fight-antimicrobial-resistance-amr.html (11 May 2023). Global Antibiotic R &amp D Alliance. Asia authorities funding assists GARDP\u00e2 $ s efforts to respond to antibiotic protection. GARDP https:\/\/gardp.org\/japan-government-funding-supports-gardps-efforts-to-counter-antibiotic-resistance\/ (19 Oct 2023). Novo Nordisk Structure. Novo Nordisk Base partners along with CARB-X to eliminate drug-resistant diseases. novo nordisk foundation https:\/\/novonordiskfonden.dk\/en\/news\/novo-nordisk-foundation-partners-with-carb-x-to-fight-drug-resistant-infections\/ (9 January 2024). International Commission: European Health and also Digital Executive Organization. Research study on bringing AMR health care countermeasures to the market. Publications Workplace of the European Union https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/51b2c82c-c21b-11ed-8912-01aa75ed71a1\/language-en (2023 ). Outterson, K. Approximating the ideal measurements of global pull rewards for antibacterial medicines. Health Aff. 40, 1758\u00e2 $ \"1765 (2021 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nEvans, E. J., Meyer, A. &amp Conti, R. M. Dimension a market access reward for the growth of brand new prescription antibiotics. Harvard Kennedy College https:\/\/www.hks.harvard.edu\/sites\/default\/files\/centers\/mrcbg\/Final_AWP_232.pdf (May 2024). Morel, C. M. et al. Sector incentives and antibiotic resistance: an introduction to the antibiotic vulnerability reward. J. Antibiot. 73, 421\u00e2 $ \"428 (2020 ). CAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nBonnifield, R. &amp Towse, A. A determined USG evolved devotion for subscription-based buying of novel antimicrobials and its own assumed roi. Facility for Global Growth https:\/\/www.cgdev.org\/publication\/ambitious-usg-advanced-commitment-subscription-based-purchasing-novel-antimicrobials (15 Nov 2022). Towse, A. &amp Silverman Bonnifield, R. G7 investments in brand new antibiotics will pay off \u00e2 $\" for everybody. Office of Wellness Business economics https:\/\/www.ohe.org\/insight\/g7-investments-in-new-antibiotics-would-pay-off-for-everyone\/ (9 December 2022). NHS England. NHS steps up war against severe diseases following successful world-first aviator. NHS England https:\/\/www.england.nhs.uk\/2023\/07\/nhs-steps-up-battle-against-life-threatening-infections-following-successful-world-first-pilot\/ (11 July 2023). United States Congress. S. 1355 \u00e2 $\" PASTEUR Process of 2023. congress.gov www.congress.gov\/bill\/118th-congress\/senate-bill\/1355#:~:text=This%20bill%20authorizes%20the%20Department,and%20contains%20other%20related%20provisions (27 April 2023). European Commission. Reform of the EU pharmaceutical legalisation. European Percentage https:\/\/health.ec.europa.eu\/medicinal-products\/pharmaceutical-strategy-europe\/reform-eu-pharmaceutical-legislation_en (26 April 2023). Gotham, D. et al. Compensation designs to attack market breakdowns for antimicrobials: strategies enjoyed France, Germany, Sweden, the United Kingdom, as well as the USA. Wellness Plan 125, 296\u00e2 $ \"306 (2020 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nInternational Federation of Drug Manufacturers and Affiliations. From protection to resilience: what could the future antibiotic pipe look like? IFMPA https:\/\/www.ifpma.org\/publications\/from-resistance-to-resilience-what-could-the-future-antibiotic-pipeline-look-like\/ (14 May 2024). International AMR R&ampD Center &amp Globe Wellness Association. Incentivising the development of brand-new antibacterial procedures: 2023 progress report by the Worldwide AMR R&ampD Hub and also That. International AMR R&ampD Hub https:\/\/globalamrhub.org\/publications\/incentivising-the-development-of-new-antibacterial-treatments-2023\/ (2023 ). Glover, R. E., Singer, A., Roberts, A. P. &amp Kirchhelle, C. Why is the UK membership style for anti-biotics thought about successful? Lancet Microbe 4, e852\u00e2 $ \"e853 (2023 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNon-paper \u00e2 $\" unique stimuli for the progression and also keeping the marketplace of antimicrobials. Politician https:\/\/www.politico.eu\/wp-content\/uploads\/2022\/12\/01\/Non-paper-Transferable-exclusivity-voucher-for-AMR-2.pdf (2022 ). Liu, L. et al. Global, regional, as well as national root causes of little one death in 2000\u00e2 $ \"thirteen, with estimates to inform post-2015 concerns: an upgraded step-by-step analysis. Lancet 385, 430\u00e2 $ \"440 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nQuadri, F. et al. Antibacterial medicine scarcities from 2001 to 2013: implications for professional practice. Clin. Corrupt. Dis. 60, 1737\u00e2 $ \"1742 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nBenhabib, A. et al. The French reporting device for medicine deficiencies: description and trends coming from 2012 to 2018: an observational retrospective research. BMJ Open 10, e034033 (2020 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nKlein, E. Y. et al. Examination of WHO antibiotic intake and also get access to intendeds in 76 nations, 2000\u00e2 $ \"15: an evaluation of pharmaceutical purchases data. Lancet Infect. Dis. 21, 107\u00e2 $ \"115 (2021 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPyzik, O. Z. &amp Abubakar, I. Combating the fakes: addressing ineffective and also falsified medications. Nat. Rev. Dis. Guides 8, 55 (2022 ). Hayhoe, B., Greenfield, G. &amp Majeed, A. Is it getting easier to secure antibiotics in the UK? Br. J. Gen. Pract. 69, 54\u00e2 $ \"55 (2019 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nBlack Culture for Lab Medication. Plan brief and also infographics on antimicrobial resistance (AMR) in Africa. ASLM https:\/\/aslm.org\/resource\/policy-brief-and-infographics-on-antimicrobial-resistance-amr-in-africa\/ (14 September 2022). Kanu, J. S. et cetera. National antibiotic usage for individual usage in Sierra Leone (2017\u00e2 $ \"2019): a cross-sectional research. Trop. Med. Corrupt. Dis. 6, 77 (2021 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nNamugambe, J. S. et cetera. National antimicrobial consumption: study of main warehouses materials to in-patient care health centers from 2017 to 2019 in Uganda. Trop. Med. Affect. Dis. 6, 83 (2021 ).\nGoogle Scholar\u00c2.\nRobertson, J. et al. Variations in the consumption of antimicrobial medicines in the European location, 2014\u00e2 $ \"2018: searchings for and also effects from ESAC-Net and WHO Europe. Face. Pharmacol. 12, 639207 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nShukar, S. et cetera. Drug deficiency: sources, effect, and also minimization tactics. Front end. Pharmacol. 12, 693426 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nOutterson, K., Orubu, E. S. F., Rex, J., \u00c3 ... rdal, C. &amp Zaman, M. H. Client gain access to in 14 high-income nations to new antibacterials approved by the US Fda, European Medicines Agency, Japanese Pharmaceuticals and also Medical Devices Agency, or Wellness Canada, 2010\u00e2 $ \"2020. Clin. Contaminate. Dis. 74, 1183\u00e2 $ \"1190 (2021 ). Article\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nPulcini, C. et al. Lost anti-biotics: a follow-up stock research study in Europe, the United States, Canada as well as Australia. Int. J. Antimicrob. Brokers 49, 98\u00e2 $ \"101 (2017 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nRottingen, J. A. &amp Farrar, J. Targeted wellness innovation for global health and wellness. Br. Med. J. 366, 15601 (2019 ).\nGoogle.com Scholar\u00c2.\nAMR Market Collaboration. The 2023 AMR Market Partnership progression questionnaire: manufacturing as well as the environment. amr Business Alliance https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/12\/AMRIA_Manufacturing-and-the-environment-FINAL.pdf (2023 ). Munoz, V., Visentin, F., Foray, D. &amp Gaule, P. Can medical items be actually created on a charitable manner? Exploring product advancement alliances for neglected health conditions. Sci. Public Policy 42, 315\u00e2 $ \"338 (2015 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nSwaminathan, S. et cetera. Reboot biomedical R&ampD in the international social enthusiasm. Attribute 602, 207\u00e2 $ \"210 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nAfrica Centres for Ailment Command and also Protection. Africa CDC directs vibrant relocate to get Africa\u00e2 $ s health and wellness future by developing a 50 billion dollar health care market. AfricaCDC https:\/\/africacdc.org\/news-item\/africa-cdc-spearheads-bold-move-to-secure-africas-health-future-by-creating-a-50-billion-dollar-medical-market\/ (19 February 2024). Blood, C., Morin, S., R\u00c3 \u00b8 ttingen, J. A. &amp Kieny, M. P. Arranging public-health intellectual property licensing agreements to increase access to wellness innovations: an insider\u00e2 $ s story. BMJ Chunk. Health 8, e012964 (2023 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nSuleman, F., Low, M., Moon, S. &amp Morgan, S. G. New service styles for trial and error with price demands are actually required to accomplish decent prices of medicines. Br. Medication. J. 368, l4408 (2020 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nCombating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator. Stewardship and gain access to. CARB-X https:\/\/carb-x.org\/about\/stewardship-and-access\/ (2024 ). Worldwide Prescription Antibiotic R &amp D Collaboration. Shinogi, GARDP and also CHAI introduce site permit as well as partnership deals to treat bacterial contaminations next to growing accessibility to cefiderocol in 135 nations. GARDP https:\/\/gardp.org\/shionogi-gardp-and-chai-announce-landmark-license-and-collaboration-agreements-to-treat-bacterial-infections-by-expanding-access-to-cefiderocol-in-135-countries\/ (15 June 2022). AMR Business Alliance. Leaving behind the lab: tracking the downtrend in AMR R&ampD professionals. amr Business Alliance https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/02\/Leaving-the-Lab_final-1.pdf (February, 2024). G7 Health Ministers. G7 Health Ministers\u00e2 $ Communiqu\u00c3 \u00a9. G7 Germany www.g7germany.de\/resource\/blob\/974430\/2042058\/5651daa321517b089cdccfaffd1e37a1\/2022-05-20-g7-health-ministers-communique-data.pdf (twenty May 2022). G20. G20 phone call to action on antimicrobial protection. G7G20 Documentations Data bank https:\/\/g7g20-documents.org\/database\/document\/2022-g20-indonesia-sherpa-track-health-ministers-ministers-annex-g20-call-to-action-on-antimicrobial-resistance (28 October 2022). Global Union on Aging &amp Transmittable Ailments Society of The United States. 2024 AMR preparedness mark progress report. Assessing government activity on AMR plan. Global Union on Growing old https:\/\/globalcoalitiononaging.com\/wp-content\/uploads\/2024\/01\/2024-AMR-Index-Progress-Report.pdf (2024 ). Meals and also Farming Organization of the United Nations, United Nations Setting Program, Globe Health And Wellness Organization &amp. World Company for Pet Health. International data bank for tracking antimicrobial protection (AMR): nation self-assessment study (TrACSS). That https:\/\/amrcountryprogress.org\/

/map-viewindicator2.3 (2023 ). Truck Katwyk, S. R. &amp Outterson K. Overview: AMR belongs in the as...

Integrating liver endpoints in scientific tests of cardiovascular and kidney condition

.Attributes Medication, Published online: 03 September 2024 doi:10.1038/ s41591-024-03223-zThis Stan...

FALSE:: MISTAKE: UNSUPPORTED ENCODING...

Artificial knowledge guided screening for cardiomyopathies in an obstetric population: a practical randomized medical test

.Trial design as well as oversightThe Screening process for PEripartum Cardiomyopathies with Artific...